Nucleosomes compact and organize genetic material on a structural level. However, they
also alter local chromatin accessibility through changes in their position, through the …

Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis.
This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for …

Chromatin is the complex of eukaryotic DNA and proteins required for the efficient
compaction of the nearly 2-meter-long human genome into a roughly 10-micron-diameter …

Tousled-like kinases (TLKs) are nuclear serine-threonine kinases essential for genome
maintenance and proper cell division in animals and plants. A major function of TLKs is to …

Gene duplication is regarded as the main source of adaptive functional novelty in
eukaryotes. Processes such as neo-and subfunctionalization impact the evolution of …

Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA
damage response is usually just regarded as an apoptotic trigger. However, growing …

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to
restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this …

The highly conserved eukaryotic histone chaperone ASF1 is involved in the assembly and
disassembly of nucleosomes during transcription, DNA replication, and repair. It was the first …

The ability of histone chaperone Anti-silencing factor 1 (Asf1) to direct acetylation of lysine
56 of histone H3 (H3K56ac) represents an important regulatory step in genome replication …

ELG1 is a conserved gene uncovered in a number of genetic screens in yeast aimed at
identifying factors important in the maintenance of genome stability. Elg1's activity prevents …