Background Morning cortisol levels have been reported to be elevated among patients with
Alzheimer's disease (AD); yet no meta-analysis has been conducted to confirm the existence …

Cortisol is the end product of the hypothalamic-pituitary-adrenal (HPA) axis, and its
production is increased mainly in stressful situations or in chronic disorders accompanied by …

Disrupted circadian activity is associated with many neuropsychiatric disorders. A major
coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits …

Background Socioeconomic position has been shown to be associated with inflammation.
However, little is known about the role of inflammation in socioeconomic inequalities in …

Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses
and immune activation, experience age-related decline, impacting systemic health …

This review outlines the various factors associated with unhealthy aging which includes
becoming frail and dependent. With many people not engaging in recommended exercise …

Neuroticism has been associated with a greater dementia risk, but its association with
cognitive decline in healthy older adults remains unclear. Stress has been proposed as one …

Background Neurocognitive impairment is common in people with Sickle Cell Disease
(SCD) and evidence is accumulating that sleep disturbances play a role. The interaction …

We rigorously investigated potential longitudinal associations of hair cortisol and cortisone
with verbal memory, time orientation, and dementia, adjusting for sociodemographic and …

With disease-modifying treatments for Alzheimer's disease (AD) still elusive, the search for
alternative intervention strategies has intensified. Growing evidence suggests that …