Ribosome specialization in cancer: a spotlight on ribosomal proteins

S Ramalho, A Dopler, WJ Faller - NAR cancer, 2024 - academic.oup.com
In the past few decades, our view of ribosomes has changed substantially. Rather than
passive machines without significant variability, it is now acknowledged that they are …

The nucleolus: Coordinating stress response and genomic stability

K González-Arzola - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2024 - Elsevier
The perception that the nucleoli are merely the organelles where ribosome biogenesis
occurs is challenged. Only around 30% of nucleolar proteins are solely involved in …

Free ribosomal proteins as culprits for nucleolar stress

I Huppertz - Molecular Cell, 2024 - Elsevier
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et
al. 1 find that the common molecular signature of nucleolar stress is the accumulation of free …