Autophagy genes in biology and disease

H Yamamoto, S Zhang, N Mizushima - Nature Reviews Genetics, 2023 - nature.com
Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Neutrophils: from IBD to the gut microbiota

C Danne, J Skerniskyte, B Marteyn… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains

D Demontis, GB Walters, G Athanasiadis, R Walters… - Nature …, 2023 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder
with a major genetic component. Here, we present a genome-wide association study meta …

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries

Z Liu, R Liu, H Gao, S Jung, X Gao, R Sun, X Liu… - Nature …, 2023 - nature.com
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …

Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study

S Xu, X Li, S Zhang, C Qi, Z Zhang, R Ma, L Xiang… - BMC medicine, 2023 - Springer
Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …

Neutralizing autoantibodies against interleukin-10 in inflammatory bowel disease

H Griffin, L Ceron-Gutierrez… - … England Journal of …, 2024 - Mass Medical Soc
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with
infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin …

Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults

L Yang, YN Ou, BS Wu, WS Liu, YT Deng… - Nature …, 2024 - nature.com
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs)
remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK …

Common genetic factors among autoimmune diseases

A Harroud, DA Hafler - Science, 2023 - science.org
Autoimmune diseases display a high degree of comorbidity within individuals and families,
suggesting shared risk factors. Over the past 15 years, genome-wide association studies …

The NF-κB signaling system in the immunopathogenesis of inflammatory bowel disease

T Mukherjee, N Kumar, M Chawla, DJ Philpott… - Science …, 2024 - science.org
Inflammatory bowel disease (IBD) is an idiopathic, chronic condition characterized by
episodes of inflammation in the gastrointestinal tract. The nuclear factor κB (NF-κB) system …

[HTML][HTML] Defining interactions between the genome, epigenome, and the environment in inflammatory bowel disease: progress and prospects

AJ Noble, JK Nowak, AT Adams, HH Uhlig, J Satsangi - Gastroenterology, 2023 - Elsevier
Recent advances in our understanding of the pathogenesis of inflammatory bowel disease
(IBD) have highlighted the complex interplay between the genome, the epigenome, and the …