Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …

Abstract mRNA localization is a common mechanism for targeting proteins to regions of the
cell where they are required. It has an essential role in localizing cytoplasmic determinants …

Duplicated genes escape gene loss by conferring a dosage benefit or evolving diverged
functions. The yeast Saccharomyces cerevisiae contains many duplicated genes encoding …

In yeast Saccharomyces cerevisiae, Ash1p, a protein determinant for mating-type switching,
is segregated within the daughter cell nucleus to establish asymmetry of HO expression. The …

A major pathway for macromolecular exchange in plants involves plasmodesmata (PD), the
small pores that connect adjoining cells. This article considers the nature of macromolecular …

Asymmetric subcellular distribution of RNA is used by many organisms to establish cell
polarity, differences in cell fate, or to sequester protein activity. Accurate localization of RNA …

Myo4p is a nonessential type V myosin required for the bud tip localization of ASH1 and
IST2 mRNA. These mRNAs associate with Myo4p via the She2p and She3p proteins. She3p …

In yeast, growth and organelle segregation requires formin-dependent assembly of
polarized actin cables. These tracks are used by myosin Vs to deliver secretory vesicles for …

Localization of messenger RNAs and local protein synthesis contribute to asymmetric
protein distribution not only of cytoplasmic but also of membrane or secreted proteins [1, 2] …

mRNA localization is a widespread post-transcriptional mechanism for targeting protein
synthesis to specific cellular sites. It is involved in the generation of cell polarity, asymmetric …