Scaled preparation of extracellular vesicles from conditioned media

S Staubach, FN Bauer, T Tertel, V Börger… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

Construction and characterization of virus-like particles: a review

A Zeltins - Molecular biotechnology, 2013 - Springer
Over the last three decades, virus-like particles (VLPs) have evolved to become a widely
accepted technology, especially in the field of vaccinology. In fact, some VLP-based …

Current challenges in biotherapeutic particles manufacturing

MG Moleirinho, RJS Silva, PM Alves… - Expert opinion on …, 2020 - Taylor & Francis
Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

In vitro assembly of virus-like particles and their applications

DT Le, KM Müller - Life, 2021 - mdpi.com
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery.
Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous …

Electrospun triaxial nanofibers with middle blank cellulose acetate layers for accurate dual-stage drug release

Y Yang, S Chang, Y Bai, Y Du, DG Yu - Carbohydrate polymers, 2020 - Elsevier
The combination of complex nanostructures with carbohydrate polymers can provide a
strong platform for promoting the development of novel drug delivery systems. In this study …

Plant-derived virus-like particles as vaccines

Q Chen, H Lai - Human vaccines & immunotherapeutics, 2013 - Taylor & Francis
Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Green synthesis of antimicrobial silver nanoparticles using fruit extract of Glycosmis pentaphylla and its theoretical explanations

T Dutta, SK Chowdhury, NN Ghosh… - Journal of Molecular …, 2022 - Elsevier
The present study reports a novel, one-pot, cost-effective, green synthesis route of silver
nanoparticles (AgNPs) from the fruit epicarp extract of Glycosmis pentaphylla (FGP). The UV …

Virus-like particles: the new frontier of vaccines for animal viral infections

E Crisci, J Bárcena, M Montoya - Veterinary immunology and …, 2012 - Elsevier
Vaccination continues to be the main approach to protect animals from infectious diseases.
Until recently, all licensed vaccines were developed using conventional technologies …

Improved virus purification processes for vaccines and gene therapy

P Nestola, C Peixoto, RRJS Silva… - Biotechnology and …, 2015 - Wiley Online Library
The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Clarification of vaccines: An overview of filter based technology trends and best practices

L Besnard, V Fabre, M Fettig, E Gousseinov… - Biotechnology …, 2016 - Elsevier
Vaccines are derived from a variety of sources including tissue extracts, bacterial cells, virus
particles, recombinant mammalian, yeast and insect cell produced proteins and nucleic …