Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

Importance The global patterns and distribution of case-fatality rates (CFRs) in pediatric
severe sepsis and septic shock remain poorly described. Objective We performed a …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Importance Sepsis is a leading cause of death among children worldwide. Current pediatric-
specific criteria for sepsis were published in 2005 based on expert opinion. In 2016, the …

Objective: To determine the associations of demographic, clinical, laboratory, organ
dysfunction, and illness severity variable values with: 1) sepsis, severe sepsis, or septic …

Objective: The epidemiology of in-hospital death after pediatric sepsis has not been well
characterized. We investigated the timing, cause, mode, and attribution of death in children …

BACKGROUND AND OBJECTIVES Definitions for pediatric sepsis were established in 2005
without data-driven criteria. It is unknown whether the more recent adult Sepsis-3 definitions …

Purpose The definitions of sepsis and septic shock have recently been revised in adults, but
contemporary data are needed to inform similar approaches in children. Methods …

Objectives: We used artificial intelligence to develop a novel algorithm using physiomarkers
to predict the onset of severe sepsis in critically ill children. Design: Observational cohort …

Objectives: In-hospital pediatric sepsis mortality has decreased substantially, but long-term
mortality and morbidity among children initially surviving sepsis, is unknown. Accordingly …