Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long
history of scientific interest and clinical use for the treatment of neoplastic and non …

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Mitochondrial dynamics, including fusion, fission and translocation, are crucial to cellular
homeostasis, with roles in cellular polarity, stress response and apoptosis. Mitochondrial …

Anillins and Mid1 are scaffold proteins that play key roles in anchorage of the contractile ring
at the cell equator during cytokinesis in animals and fungi, respectively. Here, we report …

Research on the immune system and cancer has led to the development of new medicines
that enable the former to attack cancer cells. Drugs that specifically target and destroy …

The actin cytoskeleton is a complex network of dynamic polymers, which plays an important
role in various fundamental cellular processes, including maintenance of cell shape …

Despite recent advances in our understanding of the components and spatial regulation of
the contractile ring (CR), the precise ultrastructure of actin and myosin II within the animal …

α-Actinins are a major class of actin filament cross-linking proteins expressed in virtually all
cells. In muscle, actinins cross-link thin filaments from adjacent sarcomeres. In non-muscle …

Cytokinesis has been extensively studied in different models, but the role of the extracellular
cell wall is less understood. Here we studied this process in fission yeast. The essential …

Introduction to Fission Yeast as a Model System Cold Spring Harbor Protocols Skip to main
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