Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

Actinobacteria constitute one of the largest phyla among Bacteria and represent gram-
positive bacteria with a high G+ C content in their DNA. This bacterial group includes …

Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and
man, with worldwide annual losses to agriculture of $3 billion. The human burden of …

Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

Tuberculosis remains a leading cause of death worldwide, despite the availability of
effective chemotherapy and a vaccine. Bacillus Calmette–Guérin (BCG), the tuberculosis …

The developing science called structural genomics has focused to date mainly on high-
throughput expression of individual proteins, followed by their purification and structure …

The tuberculosis (TB) vaccine bacille Calmette-Guérin (BCG) is a live attenuated organism,
but the mutation responsible for its attenuation has never been defined. Recent genetic …

Although many bacterial pathogens use specialized secretion systems for virulence, no such
systems have been described for Mycobacterium tuberculosis, a major pathogen of humans …