Developing Aspergillus niger as a cell factory for food enzyme production

C Li, J Zhou, G Du, J Chen, S Takahashi, S Liu - Biotechnology Advances, 2020 - Elsevier
Aspergillus niger has become one of the most important hosts for food enzyme production
due to its unique food safety characteristics and excellent protein secretion systems. A series …

Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

C Jo, J Zhang, JM Tam, GM Church, AS Khalil… - Materials Today Bio, 2023 - Elsevier
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Moulding the mould: understanding and reprogramming filamentous fungal growth and morphogenesis for next generation cell factories

TC Cairns, X Zheng, P Zheng, J Sun, V Meyer - Biotechnology for Biofuels, 2019 - Springer
Filamentous fungi are harnessed as cell factories for the production of a diverse range of
organic acids, proteins, and secondary metabolites. Growth and morphology have critical …

Genetic engineering of filamentous fungi for efficient protein expression and secretion

Q Wang, C Zhong, H Xiao - Frontiers in Bioengineering and …, 2020 - frontiersin.org
Filamentous fungi are considered as unique cell factories for protein production due to the
high efficiency of protein secretion and superior capability of post-translational modifications …

Engineering interventions in industrial filamentous fungal cell factories for biomass valorization

A Madhavan, KB Arun, R Sindhu, AA Jose… - Bioresource …, 2022 - Elsevier
Filamentous fungi possess versatile capabilities for synthesizing a variety of valuable bio
compounds, including enzymes, organic acids and small molecule secondary metabolites …

Aspergillus: A powerful protein production platform

F Ntana, UH Mortensen, C Sarazin, R Figge - Catalysts, 2020 - mdpi.com
Aspergilli have been widely used in the production of organic acids, enzymes, and
secondary metabolites for almost a century. Today, several GRAS (generally recognized as …

Development of the thermophilic fungus Myceliophthora thermophila into glucoamylase hyperproduction system via the metabolic engineering using improved …

Z Zhu, M Zhang, D Liu, D Liu, T Sun, Y Yang… - Microbial Cell …, 2023 - Springer
Background Glucoamylase is an important enzyme for starch saccharification in the food
and biofuel industries and mainly produced from mesophilic fungi such as Aspergillus and …

Fungal morphology: a challenge in bioprocess engineering industries for product development

HA El Enshasy - Current Opinion in Chemical Engineering, 2022 - Elsevier
Fungal biofactories are well established in bioprocess industries. They have been used for
the production of essential biomolecules in chemical, food, and pharmaceutical industries …

Something old, something new: challenges and developments in Aspergillus niger biotechnology

TC Cairns, L Barthel, V Meyer - Essays in Biochemistry, 2021 - portlandpress.com
The filamentous ascomycete fungus Aspergillus niger is a prolific secretor of organic acids,
proteins, enzymes and secondary metabolites. Throughout the last century, biotechnologists …

A quantitative image analysis pipeline for the characterization of filamentous fungal morphologies as a tool to uncover targets for morphology engineering: a case …

TC Cairns, C Feurstein, X Zheng, P Zheng, J Sun… - Biotechnology for …, 2019 - Springer
Background Fungal fermentation is used to produce a diverse repertoire of enzymes,
chemicals, and drugs for various industries. During submerged cultivation, filamentous fungi …