The past several years have witnessed an increased presence of control theoretic concepts
in synthetic biology. This review presents an organized summary of how these control …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

Homeostasis is a recurring theme in biology that ensures that regulated variables robustly—
and in some systems, completely—adapt to environmental perturbations. This robust perfect …

Quantification and regulation of pathway metabolites is crucial for optimization of microbial
production bioprocesses. Genetically encoded biosensors provide the means to couple …

The behavior of genetic circuits is often poorly predictable. A gene's expression level is not
only determined by the intended regulators, but also affected by changes in ribosome …

The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

Abstract Proportional-Integral-Derivative (PID) feedback controllers are the most widely used
controllers in industry. Recently, the design of molecular PID-controllers has been identified …

The rise of systems biology has ushered a new paradigm: the view of the cell as a system
that processes environmental inputs to drive phenotypic outputs. Synthetic biology provides …

Highlights•Synthetic biomolecular feedback controllers have promising applications in
various fields.•Negative-feedback controllers enhance dynamic performance and reduce …

There is no design template more important than DNA. Within the sequences of this
exquisite substance lie the design plans for each of us and for every living organism …