The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …

In recent years, our understanding of protein structure and function has advanced rapidly,
providing a mechanistic understanding of a wide variety of biological processes. As an …

Bioinspired polymeric materials are attracting increasing attention due to significant
advantages over their natural counterparts: the ability to precisely tune their structures over a …

The highly refined organic chemistry in solid-phase synthesis has made it the method of
choice not only to assemble peptides but also small proteins–mainly on a laboratory scale …

We have synthesized and characterized a family of structured oligo-N-substituted-glycines
(peptoids) up to 36 residues in length by using an efficient solid-phase protocol to …

A series of peptoid oligomers were designed as helical, cationic, and facially amphipathic
mimics of the magainin-2 amide antibacterial peptide. We used circular dichroism …

Peptoid oligomers were initially developed as part of a larger basic research effort to
accelerate the drug‐discovery process in the biotech/biopharma industry. Their ease of …

DNA nanotechnology has established approaches for designing programmable and
precisely controlled nanoscale architectures through specific Watson− Crick base-pairing …

Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich
sequences. However, instead of recognizing critical prolines on the basis of side chain …

Foldamers are an intriguing family of biomimetic oligomers that exhibit a propensity to adopt
stable secondary structures. N-Substituted glycine oligomers, or “peptoids”, are a …