Mini review: The FDA-approved prescription drugs that target the MAPK signaling pathway in women with breast cancer
Breast cancer (BC) is the most common cancer and the prevalent type of malignancy among
women. Multiple risk factors, including genetic changes, biological age, dense breast tissue …
women. Multiple risk factors, including genetic changes, biological age, dense breast tissue …
[HTML][HTML] Understanding the inflammation-cancer transformation in the development of primary liver cancer
HJ Chen, MH Hu, FG Xu, HJ Xu, JJ She… - Hepatoma …, 2018 - oaepublish.com
Primary liver cancer is one of the leading causes of cancer-related deaths worldwide. China
has more than 55% liver cancer cases globally. The development of hepatocellular …
has more than 55% liver cancer cases globally. The development of hepatocellular …
TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness
R Du, W Shen, Y Liu, W Gao, W Zhou, J Li… - Signal transduction and …, 2019 - nature.com
TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that plays essential
roles in the regulation of development and cell fate decisions. Aberrant expression of TGIF …
roles in the regulation of development and cell fate decisions. Aberrant expression of TGIF …
Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma
Background Elafin is a serine protease inhibitor critical for host defence. We previously
reported that Elafin was associated with the recurrence of early-stage hepatocellular …
reported that Elafin was associated with the recurrence of early-stage hepatocellular …
[HTML][HTML] Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huh‑7 cells by regulating the ERK‑VEGF/MMP9 signaling pathway
Y Chen, X Chen, X Ding… - Molecular medicine …, 2019 - spandidos-publications.com
Transcatheter arterial embolization (TAE) therapy has been used in the treatment of
inoperable hepatocellular carcinoma (HCC). However, tumor recurrence and metastasis are …
inoperable hepatocellular carcinoma (HCC). However, tumor recurrence and metastasis are …
Blockade of the P2Y2 receptor attenuates alcoholic liver inflammation by targeting the EGFR-ERK1/2 signaling pathway
ZN Liu, QQ Su, YH Wang, X Wu… - Drug Design, Development …, 2022 - Taylor & Francis
Purpose It is well known that inflammation plays a key role in complex pathological
progressions of alcohol-associated liver disease (ALD). To date, effective therapy for ALD is …
progressions of alcohol-associated liver disease (ALD). To date, effective therapy for ALD is …
Reticulocalbin3: A Ca2+ homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance
R Cai, P Wang, X Zhao, X Lu, R Deng, X Wang… - Cancer …, 2022 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers
worldwide. There is a critical need to identify new mechanisms that contribute to ESCC …
worldwide. There is a critical need to identify new mechanisms that contribute to ESCC …
Quantitative proteomic analysis of cervical cancer tissues identifies proteins associated with cancer progression
A Ramirez-Torres, J Gil, S Contreras… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: To date, several proteomics studies in cervical cancer (CC) have focused
mainly on squamous cervical cancer (SCC). Our study aimed to discover and clarify …
mainly on squamous cervical cancer (SCC). Our study aimed to discover and clarify …
EGFR activation impairs antiviral activity of interferon signaling in brain microvascular endothelial cells during Japanese encephalitis virus infection
YG Zhang, HW Chen, HX Zhang, K Wang… - Frontiers in …, 2022 - frontiersin.org
The establishment of Japanese encephalitis virus (JEV) infection in brain microvascular
endothelial cells (BMECs) is thought to be a critical step to induce viral encephalitis with …
endothelial cells (BMECs) is thought to be a critical step to induce viral encephalitis with …
[HTML][HTML] Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic …
X Zhu, M Hu, H Ji, T Huang, RS Ge, Y Wang - … and Environmental Safety, 2021 - Elsevier
Humans are exposed to phthalates ubiquitously, which may threaten health. However,
whether di-n-octyl phthalate can prevent pubertal sexual maturity is still elusive. In this study …
whether di-n-octyl phthalate can prevent pubertal sexual maturity is still elusive. In this study …