Mini review: The FDA-approved prescription drugs that target the MAPK signaling pathway in women with breast cancer

F Khojasteh Poor, M Keivan, M Ramazii… - Breast …, 2021 - content.iospress.com
Breast cancer (BC) is the most common cancer and the prevalent type of malignancy among
women. Multiple risk factors, including genetic changes, biological age, dense breast tissue …

[HTML][HTML] Understanding the inflammation-cancer transformation in the development of primary liver cancer

HJ Chen, MH Hu, FG Xu, HJ Xu, JJ She… - Hepatoma …, 2018 - oaepublish.com
Primary liver cancer is one of the leading causes of cancer-related deaths worldwide. China
has more than 55% liver cancer cases globally. The development of hepatocellular …

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness

R Du, W Shen, Y Liu, W Gao, W Zhou, J Li… - Signal transduction and …, 2019 - nature.com
TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that plays essential
roles in the regulation of development and cell fate decisions. Aberrant expression of TGIF …

Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma

C Wang, Y Liao, W He, H Zhang, D Zuo, W Liu… - Journal of Experimental …, 2021 - Springer
Background Elafin is a serine protease inhibitor critical for host defence. We previously
reported that Elafin was associated with the recurrence of early-stage hepatocellular …

[HTML][HTML] Afatinib, an EGFR inhibitor, decreases EMT and tumorigenesis of Huh‑7 cells by regulating the ERK‑VEGF/MMP9 signaling pathway

Y Chen, X Chen, X Ding… - Molecular medicine …, 2019 - spandidos-publications.com
Transcatheter arterial embolization (TAE) therapy has been used in the treatment of
inoperable hepatocellular carcinoma (HCC). However, tumor recurrence and metastasis are …

Blockade of the P2Y2 receptor attenuates alcoholic liver inflammation by targeting the EGFR-ERK1/2 signaling pathway

ZN Liu, QQ Su, YH Wang, X Wu… - Drug Design, Development …, 2022 - Taylor & Francis
Purpose It is well known that inflammation plays a key role in complex pathological
progressions of alcohol-associated liver disease (ALD). To date, effective therapy for ALD is …

Reticulocalbin3: A Ca2+ homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance

R Cai, P Wang, X Zhao, X Lu, R Deng, X Wang… - Cancer …, 2022 - Wiley Online Library
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers
worldwide. There is a critical need to identify new mechanisms that contribute to ESCC …

Quantitative proteomic analysis of cervical cancer tissues identifies proteins associated with cancer progression

A Ramirez-Torres, J Gil, S Contreras… - Cancer Genomics & …, 2022 - cgp.iiarjournals.org
Background/Aim: To date, several proteomics studies in cervical cancer (CC) have focused
mainly on squamous cervical cancer (SCC). Our study aimed to discover and clarify …

EGFR activation impairs antiviral activity of interferon signaling in brain microvascular endothelial cells during Japanese encephalitis virus infection

YG Zhang, HW Chen, HX Zhang, K Wang… - Frontiers in …, 2022 - frontiersin.org
The establishment of Japanese encephalitis virus (JEV) infection in brain microvascular
endothelial cells (BMECs) is thought to be a critical step to induce viral encephalitis with …

[HTML][HTML] Exposure to di-n-octyl phthalate during puberty induces hypergonadotropic hypogonadism caused by Leydig cell hyperplasia but reduced steroidogenic …

X Zhu, M Hu, H Ji, T Huang, RS Ge, Y Wang - … and Environmental Safety, 2021 - Elsevier
Humans are exposed to phthalates ubiquitously, which may threaten health. However,
whether di-n-octyl phthalate can prevent pubertal sexual maturity is still elusive. In this study …