Boron-containing compounds (BCC) have emerged as important pharmacophores. To date,
five BCC drugs (including boronic acids and boroles) have been approved by the FDA for …

Boron-containing molecules have been extensively used for the purposes of chemical
sensing, biological probe development and drug discovery. Due to boron's empty p orbital, it …

Protein expression and turnover are controlled through a complex interplay of
transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and …

A standard goal of medicinal chemists has been to discover efficient and potent drug
candidates with specific enzyme-inhibitor abilities. In this regard, boron-based bioactive …

Research related to boronic acids, from synthetic development to materials to drug
discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation …

Introduction: Throughout history, natural products (NPs) have provided a rich source of
compounds that have wide applications in the fields of medicine, health sciences, pharmacy …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …

Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …

Single particle cryo-electron microscopy (cryo-EM) has matured into a robust method for the
determination of biological macromolecule structures in the past decade, complementing X …