Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
G Xourafa, M Korbmacher, M Roden - Nature Reviews Endocrinology, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
[HTML][HTML] Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy
C Brito Nunes, MC Borges, RM Freathy, DA Lawlor… - Metabolites, 2024 - mdpi.com
Background/Objectives: During pregnancy, physiological changes in maternal circulating
glucose levels and its metabolism are essential to meet maternal and fetal energy demands …
glucose levels and its metabolism are essential to meet maternal and fetal energy demands …
Sex-and body mass index-specific reference intervals for serum leptin: A population based study in China
J Cheng, Y Luo, Y Li, F Zhang, X Zhang, X Zhou… - Nutrition & …, 2022 - Springer
Background Leptin is a peptide hormone secreted by adipose tissue and is an important
determinant of obesity and its complications. The purpose of this study was to establish sex …
determinant of obesity and its complications. The purpose of this study was to establish sex …
Hypoglycemic mechanisms of Polygonatum sibiricum polysaccharide in db/db mice via regulation of glycolysis/gluconeogenesis pathway and alteration of gut …
X Chen, Y Tong, Z Ren, S Chen, X Mei, Q Zhou, G Dai - Heliyon, 2023 - cell.com
Polygonatum rhizoma polysaccharide (PP) is a main ingredient of Polygonatum rhizoma,
which is both food and traditional herbal medicine. In this study, we aimed to investigate the …
which is both food and traditional herbal medicine. In this study, we aimed to investigate the …
Smoking status and type 2 diabetes, and cardiovascular disease: a comprehensive analysis of shared genetic etiology and causal relationship
Objective This study aimed to explore shared genetic etiology and the causality between
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …
smoking status and type 2 diabetes (T2D), cardiovascular diseases (CVDs), and related …
Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of β-cell function …
Background In vitro and in vivo studies have shown that certain cytokines and hormones
may play a role in the development and progression of type 2 diabetes (T2D). However …
may play a role in the development and progression of type 2 diabetes (T2D). However …
Whole-Exome Sequencing in Family Trios Reveals De Novo Mutations Associated with Type 1 Diabetes Mellitus
M Mousa, S Albarguthi, M Albreiki, Z Farooq, S Sajid… - Biology, 2023 - mdpi.com
Simple Summary Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition in
which the immune system destroys insulin-making cells in the pancreas. Many advances …
which the immune system destroys insulin-making cells in the pancreas. Many advances …
[HTML][HTML] The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population
Background and aims At the same BMI, Asian populations develop cardiometabolic
complications earlier than Western populations. We hypothesized that a different secretion …
complications earlier than Western populations. We hypothesized that a different secretion …
Genome-wide association study and polygenic score assessment of insulin resistance
Insulin resistance (IR) and beta cell dysfunction are the major drivers of type 2 diabetes
(T2D). Genome-Wide Association Studies (GWAS) on IR have been predominantly …
(T2D). Genome-Wide Association Studies (GWAS) on IR have been predominantly …
eQTLs as causal instruments for the reconstruction of hormone linked gene networks
Hormones act within in highly dynamic systems and much of the phenotypic response to
variation in hormone levels is mediated by changes in gene expression. The increase in the …
variation in hormone levels is mediated by changes in gene expression. The increase in the …