Regulating a key mitotic regulator, polo‐like kinase 1 (PLK1)
EG Colicino, H Hehnly - Cytoskeleton, 2018 - Wiley Online Library
During cell division, duplicated genetic material is separated into two distinct daughter cells.
This process is essential for initial tissue formation during development and to maintain …
This process is essential for initial tissue formation during development and to maintain …
Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution
Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …
Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications
Abstract Polo-like kinase 1 (PLK1) is a conserved mitotic serine-threonine protein kinase,
functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It …
functions as a regulatory protein, and is involved in the progression of the mitotic cycle. It …
Understanding the polo kinase machine
V Archambault, G Lepine, D Kachaner - Oncogene, 2015 - nature.com
Abstract The Polo Kinase is a central regulator of cell division required for several events of
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei
MR McAllaster, KN Ikeda… - Molecular biology of …, 2015 - Am Soc Cell Biol
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating
disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is …
disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is …
[HTML][HTML] Combined Inhibition of UBE2C and PLK1 Reduce Cell Proliferation and Arrest Cell Cycle by Affecting ACLY in Pan-Cancer
K Liang, Q Wang, L Qiu, X Gong, Z Chen… - International Journal of …, 2023 - mdpi.com
Various studies have shown that the cell-cycle-related regulatory proteins UBE2C, PLK1,
and BIRC5 promote cell proliferation and migration in different types of cancer. However …
and BIRC5 promote cell proliferation and migration in different types of cancer. However …
Recent advances in development of hetero-bivalent kinase inhibitors
Identifying a pharmacological agent that targets only one of more than 500 kinases present
in humans is an important challenge. One potential solution to this problem is the …
in humans is an important challenge. One potential solution to this problem is the …
Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma
Glioblastoma (GBM) is one of the most aggressive central nervous system tumors with a
patient's median survival of< 1 year. Polo-like kinases (PLKs) are a family of …
patient's median survival of< 1 year. Polo-like kinases (PLKs) are a family of …
PLK‐1 targeted inhibitors and their potential against tumorigenesis
Mitotic kinases are the key components of the cell cycle machinery and play vital roles in cell
cycle progression. PLK‐1 (Polo‐like kinase‐1) is a crucial mitotic protein kinase that plays …
cycle progression. PLK‐1 (Polo‐like kinase‐1) is a crucial mitotic protein kinase that plays …
BI6727 and GSK461364A, potent PLK1 inhibitors induce G2/M arrest and apoptosis against cholangiocarcinoma cell lines
H Riantana, O Waenphimai, P Mahalapbutr… - … -Research and Practice, 2023 - Elsevier
Abstract Polo-like kinase 1 (PLK1) is an essential mitotic checkpoint protein that plays a key
role in cell cycle division. Overexpression of PLK1 has been associated with poor prognosis …
role in cell cycle division. Overexpression of PLK1 has been associated with poor prognosis …