[HTML][HTML] From biology to treatment of monoclonal gammopathies of neurological significance

A Visentin, S Pravato, F Castellani, M Campagnolo… - Cancers, 2022 - mdpi.com
Simple Summary The peripheral nervous systems may be involved by several
hematological diseases ranging from preneoplastic diseases to overt malignancies or …

Update on therapy of chronic immune-mediated neuropathies

C Briani, D Cocito, M Campagnolo, PE Doneddu… - Neurological …, 2021 - Springer
Chronic immune-mediated neuropathies, including chronic inflammatory demyelinating
polyradiculoneuropathy (CIDP), neuropathies associated with monoclonal gammopathy …

Mutational Profile in 75 Patients With Anti–Myelin-Associated Glycoprotein Neuropathy: Clinical and Hematologic Therapy Response and Hints on New Therapeutic …

F Castellani, A Visentin, E Schirinzi… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Neuropathy with antibodies to myelin-associated glycoprotein
(MAG) is the most common paraproteinemic IgM neuropathy. Recently, the mutational profile …

The Bruton tyrosine kinase inhibitor ibrutinib improves anti-MAG antibody polyneuropathy

F Castellani, A Visentin, M Campagnolo… - Neurology …, 2020 - AAN Enterprises
Objective To assess whether neuropathy with anti-myelin-associated glycoprotein (MAG)
antibody may improve after treatment with ibrutinib, an oral inhibitor of Bruton tyrosine …

The BCL2 inhibitor venetoclax plus rituximab is active in MYD88 wild-type polyneuropathy with anti-MAG antibodies

C Briani, A Visentin, F Castellani… - Neurology …, 2022 - AAN Enterprises
Objectives Ibrutinib is active in anti–myelin-associated glycoprotein (MAG) polyneuropathy
with MYD88L265P mutation; however, its efficacy is likely to be low in MYD88 wild-type …

Frequency of diabetes and other comorbidities in chronic inflammatory demyelinating polyradiculoneuropathy and their impact on clinical presentation and response …

PE Doneddu, D Cocito, F Manganelli… - Journal of Neurology …, 2020 - jnnp.bmj.com
Objectives To determine the prevalence of different comorbidities in chronic inflammatory
demyelinating polyradiculoneuropathy (CIDP), and their impact on outcome, treatment …

Paraproteinemic neuropathies

SR Beydoun, L Darki - CONTINUUM: Lifelong Learning in …, 2023 - journals.lww.com
OBJECTIVE Coexistence of polyneuropathy and gammopathy is a common but potentially
challenging situation in clinical practice. This article reviews the clinical, electrophysiologic …

Bruton tyrosine kinase inhibitors: can they be optimized for the treatment of neuroinflammatory disorders?

A Visentin, M Puthenparampil… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Bruton's tyrosine kinase (BTK) is a multifaceted player of the immune system
which has been involved in the survival of hematological malignancies but also in the …

Sural nerve biopsy: current role and comparison with serum neurofilament light chain levels

S Mariotto, S Carta, S Bozzetti, C Zivelonghi… - Journal of …, 2020 - Springer
The diagnosis of peripheral neuropathies can be challenging with consequent difficulties in
patients' management. The aim of this study was to explore the current diagnostic role of …

Neurolymphomatosis, a rare manifestation of peripheral nerve involvement in lymphomas: Suggestive features and diagnostic challenges

M Campagnolo, M Cacciavillani… - Journal of the …, 2020 - Wiley Online Library
Neurolymphomatosis, the infiltration of the peripheral nervous system from lymphoid cells,
represents an uncommon manifestation of lymphomas. We describe the challenging …