During the last two decades, the number of sequence-known proteins has increased rapidly.
In contrast, the corresponding increment for structure-known proteins is much slower. The …

Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric ligand-gated ion
channels abundant in the central nervous system and are prolific drug targets for treating …

The γ-aminobutyric acid type A (GABAA) receptors are the major inhibitory neuronal
receptors in the mammalian brain. Their activation by GABA opens the intrinsic ion channel …

The sleep-aids zolpidem and eszopiclone exert their effects by binding to and modulating γ-
aminobutyric acid type-A receptors (GABAARs), but little is known about the structural …

Each GABAA receptor consists of two α and three other subunits. The spatial and temporal
distribution of different α subunit isomeres expressed by the CNS is highly regulated. Here …

GABA is the main inhibitory neurotransmitter in the mammalian central nervous system.
When GABA binds to the ubiquitous GABA-A receptors on neurons, chloride channels are …

Abstract α5 subunit-containing γ-aminobutyric acid type A (GABAA) receptors represent a
promising drug target for neurological and neuropsychiatric disorders. Altered expression …

With flavone as a structural template, three-dimensional quantitative structure− activity
relationship (3D-QSAR) studies and ab initio calculations were performed on a series of …

Abstract A series of new 6, 8-dichloro-imidazo [1, 2-a] pyridine derivatives incorporating
pyridine, thiazole, and pyrazole ring systems was synthesized. The synthetic strategy of …

Tracazolate, a pyrazolopyridine, is an anxiolytic known to interact with γ-aminobutyric acid
(GABA) A receptors, adenosine receptors, and phosphodiesterases. Its anxiolytic effect is …