Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

Human papillomaviruses (HPVs) are associated with a number of clinical conditions, of
which the most serious is cervical carcinoma. The E6 protein of the oncogenic, mucosal …

Much recent work is directt to deWeating how tk biochemical activities of~ 53 contribute to~
53 biological function. p53 probably induces a GI/S phase arrest through the combined …

To analyze the involvement of p53‐dependent transcriptional activation in normal
development and in response to DNA damage in vivo, we created transgenic mice with a …

The tumor suppressor gene product p53 plays an important role in the cellular response to
DNA damage. DNA damage can lead to p53‐mediated growth arrest and apoptosis. High …

Highly purified p53 protein from different sources was able to degrade DNA with a 3′-to-
5′ polarity, yielding deoxynucleoside monophosphates as reaction products. This …

Background Abnormalities of the p53 tumour suppressor gene are thought to be central to
the development of a high proportion of human tumours. This article reviews current …

The p53 tumor‐suppressor gene product is frequently inactivated in malignancies by point
mutation. Although most tumor‐derived p53 mutants show loss of sequence specific …