Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration
K Bharti, AI den Hollander, A Lakkaraju, D Sinha… - Experimental eye …, 2022 - Elsevier
Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …
[HTML][HTML] Implications of genetic variation in the complement system in age-related macular degeneration
Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …
in the Western world. While AMD is a multifactorial disease, the complement system was …
[HTML][HTML] Therapy approaches for Stargardt disease
E Piotter, ME McClements, RE MacLaren - Biomolecules, 2021 - mdpi.com
Despite being the most prevalent cause of inherited blindness in children, Stargardt disease
is yet to achieve the same clinical trial success as has been achieved for other inherited …
is yet to achieve the same clinical trial success as has been achieved for other inherited …
Effects and mechanisms of action of light-emitting diodes on the human retina and internal clock
Y Touitou, S Point - Environmental Research, 2020 - Elsevier
White light-emitting diodes (LEDs) will likely become the most used lighting devices
worldwide in the future because of their very low prices over the course of their long …
worldwide in the future because of their very low prices over the course of their long …
[HTML][HTML] Therapeutic potential of bixin on inflammation: a mini review
Chronic inflammation is the underlying mechanism for many diseases. Thus, inflammatory
signaling pathways are valuable targets for new treatment modalities. Natural products have …
signaling pathways are valuable targets for new treatment modalities. Natural products have …
N-retinylidene-N-retinylethanolamine adduct induces expression of chronic inflammation cytokines in retinal pigment epithelium cells
C Scimone, L Donato, S Alibrandi, M Vadalà… - Experimental Eye …, 2021 - Elsevier
Blindness due to photoreceptor degeneration is observed in both genetic and acquired eye
disorders. Long blue light exposure can contribute to increase levels of oxidative …
disorders. Long blue light exposure can contribute to increase levels of oxidative …
[HTML][HTML] Effects of A2E-induced oxidative stress on retinal epithelial cells: new insights on differential gene response and retinal dystrophies
L Donato, R D'Angelo, S Alibrandi, C Rinaldi, A Sidoti… - Antioxidants, 2020 - mdpi.com
Oxidative stress represents one of the principal inductors of lifestyle-related and genetic
diseases. Among them, inherited retinal dystrophies, such as age-related macular …
diseases. Among them, inherited retinal dystrophies, such as age-related macular …
Lutein and zeaxanthin reduce A2E and iso-A2E levels and improve visual performance in Abca4−/−/Bco2−/− double knockout mice
Accumulation of bisretinoids such as A2E and its isomer iso-A2E is thought to mediate blue
light-induced oxidative damage associated with age-related macular degeneration (AMD) …
light-induced oxidative damage associated with age-related macular degeneration (AMD) …
[HTML][HTML] Stem cell therapy in stargardt disease: a systematic review
AM Fard, R Mirshahi, M Naseripour… - Journal of Ophthalmic …, 2023 - ncbi.nlm.nih.gov
This article aimed to review current literature on the safety and efficacy of stem cell therapy
in Stargardt disease. A comprehensive literature search was performed, and two animal and …
in Stargardt disease. A comprehensive literature search was performed, and two animal and …
Long-chain polyunsaturated fatty acids and their metabolites regulate inflammation in age-related macular degeneration
J Ren, A Ren, X Deng, Z Huang, Z Jiang… - Journal of …, 2022 - Taylor & Francis
Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence
strongly increases with ages. The etiology of AMD is complex, including aging, abnormal …
strongly increases with ages. The etiology of AMD is complex, including aging, abnormal …