Genetics and neurobiology of eating disorders

CM Bulik, JRI Coleman, JA Hardaway… - Nature …, 2022 - nature.com
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

The neurobiology of food intake in an obesogenic environment

HR Berthoud - Proceedings of the Nutrition Society, 2012 - cambridge.org
The objective of this non-systematic review of the literature is to highlight some of the neural
systems and pathways that are affected by the various intake-promoting aspects of the …

Food reward, hyperphagia, and obesity

HR Berthoud, NR Lenard… - American Journal of …, 2011 - journals.physiology.org
Given the unabated obesity problem, there is increasing appreciation of expressions like
“my eyes are bigger than my stomach,” and recent studies in rodents and humans suggest …

Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa

NM Avena, ME Bocarsly - Neuropharmacology, 2012 - Elsevier
Food intake is mediated, in part, through brain pathways for motivation and reinforcement.
Dysregulation of these pathways may underlay some of the behaviors exhibited by patients …

Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal

S Sharma, MF Fernandes, S Fulton - International journal of obesity, 2013 - nature.com
Objective: To identify the emotional and motivational processes that reinstate palatable food
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …

CRF system recruitment mediates dark side of compulsive eating

P Cottone, V Sabino, M Roberto… - Proceedings of the …, 2009 - National Acad Sciences
Dieting to control body weight involves cycles of deprivation from palatable food that can
promote compulsive eating. The present study shows that rats withdrawn from intermittent …

Motivation for palatable food despite consequences in an animal model of binge eating

KD Oswald, DL Murdaugh, VL King… - … journal of eating …, 2011 - Wiley Online Library
Objective: Binge eating involves an abnormal motivation for highly palatable food in that
these foods are repeatedly consumed despite their binge‐triggering effects and life‐affecting …

High trait impulsivity predicts food addiction-like behavior in the rat

C Velázquez-Sánchez, A Ferragud, CF Moore… - …, 2014 - nature.com
Impulsivity is a behavioral trait frequently seen not only in drug-addicted individuals but also
in individuals who pathologically overeat. However, whether impulsivity predates the …

Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating

SL Kirkpatrick, LR Goldberg, N Yazdani, RK Babbs… - Biological …, 2017 - Elsevier
Background Eating disorders are lethal and heritable; however, the underlying genetic
factors are unknown. Binge eating is a highly heritable trait associated with eating disorders …

The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats

A Ferragud, AD Howell, CF Moore, TL Ta… - …, 2017 - nature.com
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of
obesity and eating disorders, as well as of the recently proposed disorder of food addiction …