Genetics and neurobiology of eating disorders
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
The neurobiology of food intake in an obesogenic environment
HR Berthoud - Proceedings of the Nutrition Society, 2012 - cambridge.org
The objective of this non-systematic review of the literature is to highlight some of the neural
systems and pathways that are affected by the various intake-promoting aspects of the …
systems and pathways that are affected by the various intake-promoting aspects of the …
Food reward, hyperphagia, and obesity
HR Berthoud, NR Lenard… - American Journal of …, 2011 - journals.physiology.org
Given the unabated obesity problem, there is increasing appreciation of expressions like
“my eyes are bigger than my stomach,” and recent studies in rodents and humans suggest …
“my eyes are bigger than my stomach,” and recent studies in rodents and humans suggest …
Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa
NM Avena, ME Bocarsly - Neuropharmacology, 2012 - Elsevier
Food intake is mediated, in part, through brain pathways for motivation and reinforcement.
Dysregulation of these pathways may underlay some of the behaviors exhibited by patients …
Dysregulation of these pathways may underlay some of the behaviors exhibited by patients …
Adaptations in brain reward circuitry underlie palatable food cravings and anxiety induced by high-fat diet withdrawal
Objective: To identify the emotional and motivational processes that reinstate palatable food
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …
CRF system recruitment mediates dark side of compulsive eating
Dieting to control body weight involves cycles of deprivation from palatable food that can
promote compulsive eating. The present study shows that rats withdrawn from intermittent …
promote compulsive eating. The present study shows that rats withdrawn from intermittent …
Motivation for palatable food despite consequences in an animal model of binge eating
KD Oswald, DL Murdaugh, VL King… - … journal of eating …, 2011 - Wiley Online Library
Objective: Binge eating involves an abnormal motivation for highly palatable food in that
these foods are repeatedly consumed despite their binge‐triggering effects and life‐affecting …
these foods are repeatedly consumed despite their binge‐triggering effects and life‐affecting …
High trait impulsivity predicts food addiction-like behavior in the rat
C Velázquez-Sánchez, A Ferragud, CF Moore… - …, 2014 - nature.com
Impulsivity is a behavioral trait frequently seen not only in drug-addicted individuals but also
in individuals who pathologically overeat. However, whether impulsivity predates the …
in individuals who pathologically overeat. However, whether impulsivity predates the …
Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating
SL Kirkpatrick, LR Goldberg, N Yazdani, RK Babbs… - Biological …, 2017 - Elsevier
Background Eating disorders are lethal and heritable; however, the underlying genetic
factors are unknown. Binge eating is a highly heritable trait associated with eating disorders …
factors are unknown. Binge eating is a highly heritable trait associated with eating disorders …
The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats
A Ferragud, AD Howell, CF Moore, TL Ta… - …, 2017 - nature.com
Compulsive, binge eating of highly palatable food constitutes a core feature of some forms of
obesity and eating disorders, as well as of the recently proposed disorder of food addiction …
obesity and eating disorders, as well as of the recently proposed disorder of food addiction …