[HTML][HTML] Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
Fibrosis: from mechanisms to medicines
NC Henderson, F Rieder, TA Wynn - Nature, 2020 - nature.com
Fibrosis can affect any organ and is responsible for up to 45% of all deaths in the
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
industrialized world. It has long been thought to be relentlessly progressive and irreversible …
TGF-β1–a truly transforming growth factor in fibrosis and immunity
M Lodyga, B Hinz - Seminars in cell & developmental biology, 2020 - Elsevier
Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
EH Budi, JR Schaub, M Decaris, S Turner… - The Journal of …, 2021 - Wiley Online Library
Many chronic diseases are marked by fibrosis, which is defined by an abundance of
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …
activated fibroblasts and excessive deposition of extracellular matrix, resulting in loss of …
TGF-β1 signaling and tissue fibrosis
KK Kim, D Sheppard… - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …
wound repair in many organs. However, the outcome of temporary extracellular matrix …
Liver fibrosis: Direct antifibrotic agents and targeted therapies
Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …
patients with chronic liver disease. Their prevention or reversal have become major …
[HTML][HTML] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis
M Yoshida, S Minagawa, J Araya, T Sakamoto… - Nature …, 2019 - nature.com
Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …
[HTML][HTML] RGD-binding integrins revisited: how recently discovered functions and novel synthetic ligands (re-) shape an ever-evolving field
Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …
investigated as therapeutic targets over the last decades, motivated by their multiple …
[HTML][HTML] The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
B Hinz - Matrix biology, 2015 - Elsevier
Physiological tissue repair aims at restoring the mechano-protective properties of the
extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring …
extracellular matrix. Consequently, redundant regulatory mechanisms are in place ensuring …