The principal function of CRISPR–Cas systems in archaea and bacteria is defence against
mobile genetic elements (MGEs), including viruses, plasmids and transposons. However …

Bacteriophages (phages) are biological entities that have attracted a great deal of attention
in recent years. They have been reported as the most abundant biological entities on the …

Due to a constant attack by phage, bacteria in the environment have evolved diverse
mechanisms to defend themselves. Several reviews on phage resistance mechanisms have …

Antibiotic resistance threatens our ability to treat infectious diseases, spurring interest in
alternative antimicrobial technologies. The use of bacterial conjugation to deliver CRISPR …

The development of antibiotic resistance in bacteria is a major public health threat. Infection
rates of resistant pathogens continue to rise against nearly all antimicrobials, which has led …

With the increasing global threat of antibiotic resistance, there is an urgent need to develop
new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage …

In this article we explain how current events in the field of phage therapy may positively
influence its future development. We discuss the shift in position of the authorities …

Targeted genome editing using CRISPR-Cas9 has been widely adopted as a genetic
engineering tool in various biological systems. This editing technology has been in the …

The biological functions of bacteriophage virions come down to the solution of three basic
problems: to provide protection of viral nucleic acid from the factors of extracellular …

The emergence and spread of antimicrobial resistance in pathogenic bacteria of fish and
shellfish have caused serious concerns in the aquaculture industry, owing to the potential …