Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics

F Gong, N Yang, X Wang, Q Zhao, Q Chen, Z Liu… - Nano Today, 2020 - Elsevier
The design and development of tumor microenvironment (TME)-responsive intelligent
nanoplatforms have attracted increasing interest to enhance the therapeutic effects of drugs …

Biocompatibility of hydrogel-based scaffolds for tissue engineering applications

S Naahidi, M Jafari, M Logan, Y Wang, Y Yuan… - Biotechnology …, 2017 - Elsevier
Recently, understanding of the extracellular matrix (ECM) has expanded rapidly due to the
accessibility of cellular and molecular techniques and the growing potential and value for …

Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks

DR Griffin, WM Weaver, PO Scumpia, D Di Carlo… - Nature materials, 2015 - nature.com
Injectable hydrogels can provide a scaffold for in situ tissue regrowth and regeneration, yet
gel degradation before tissue reformation limits the gels' ability to provide physical support …

Hydrogel scaffolds for tissue engineering: Progress and challenges

IM El-Sherbiny, MH Yacoub - Global Cardiology Science and Practice, 2013 - qscience.com
Designing of biologically active scaffolds with optimal characteristics is one of the key factors
for successful tissue engineering. Recently, hydrogels have received a considerable interest …

Design properties of hydrogel tissue-engineering scaffolds

J Zhu, RE Marchant - Expert review of medical devices, 2011 - Taylor & Francis
This article summarizes the recent progress in the design and synthesis of hydrogels as
tissue-engineering scaffolds. Hydrogels are attractive scaffolding materials owing to their …

Designing degradable hydrogels for orthogonal control of cell microenvironments

PM Kharkar, KL Kiick, AM Kloxin - Chemical Society Reviews, 2013 - pubs.rsc.org
Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …

Achieving controlled biomolecule–biomaterial conjugation

CD Spicer, ET Pashuck, MM Stevens - Chemical reviews, 2018 - ACS Publications
The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …

Biomimetic delivery of signals for bone tissue engineering

M Dang, L Saunders, X Niu, Y Fan, PX Ma - Bone research, 2018 - nature.com
Bone tissue engineering is an exciting approach to directly repair bone defects or engineer
bone tissue for transplantation. Biomaterials play a pivotal role in providing a template and …

Cell-laden microengineered gelatin methacrylate hydrogels

JW Nichol, ST Koshy, H Bae, CM Hwang, S Yamanlar… - Biomaterials, 2010 - Elsevier
The cellular microenvironment plays an integral role in improving the function of
microengineered tissues. Control of the microarchitecture in engineered tissues can be …