In comparison to procedures used for the separation of individual cell types from other
organs, the process of human pancreatic islet isolation aims to digest the pancreatic …

Background and aims Successful clinical human allo or auto-islet transplantation requires
the recovery of a sufficient number of functional islets from either brain-dead or chronic …

Muscle stem cells, termed satellite cells (SC), and SC-derived myogenic progenitor cells
(MPC) are involved in postnatal muscle growth, regeneration, and muscle adaptability. They …

Background We evaluated 3 commercially available enzymes for pancreatic digestion by
comparing key parameters during the islet isolation process, as well as islet quality after …

Clostripain secreted from Clostridium histolyticum is the founding member of the C11 family
of Clan CD cysteine peptidases, which is an important group of peptidases secreted by …

Background: Effective digestive enzymes are crucial for successful islet isolation.
Supplemental proteases are essential because they synergize with collagenase for effective …

Animal-free (AF) SERVA Collagenase AF-1 and Neutral Protease (NP) AF GMP Grade have
recently become available for human islet isolation. This report describes the initial …

Islet transplantation is a minimally invasive β‐cell replacement strategy. Islet transplantation
is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of …

Background: This presentation of a six-year study processing human islets for research and
transplantation includes a review of multi-center transplant studies identifying key variables …

Tacrolimus and sirolimus are important immunosuppressive drugs used in human islet
transplantation; however, they are linked to detrimental effects on islets and reduction of …