The past two decades in research has revealed the importance of leucine-rich repeat kinase
2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families …

In the past two decades, mutations in multiple genes have been linked to autosomal
dominant or recessive forms of monogenic Parkinson's disease (PD). Collectively, these …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial
Parkinson's disease. LRRK2 is a multi-domain protein containing a kinase and GTPase …

Background Leucine‐rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's
disease (PD) and inflammatory bowel disorders. However, the penetrance of the most …

Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit
maps are increasingly available, knowledge of their underlying molecular networks remains …

Background Mutations in LRRK2 are the most common cause of autosomal dominant
Parkinson's disease, and the relevance of LRRK2 to the sporadic form of the disease is …

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein with both a Ras of
complex (ROC) domain and a kinase domain (KD) and, therefore, exhibits both GTPase and …

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause
of the inherited form of Parkinson's disease (PD), while LRRK2 overactivation is also …

Leucine-Rich Repeat Kinase 2 (LRRK2) is a large, multidomain protein with dual kinase and
GTPase function that is commonly mutated in both familial and idiopathic Parkinson's …

Variants in the GBA1 and LRRK2 genes are the most common genetic risk factors
associated with Parkinson disease (PD). Both genes are associated with lysosomal and …