The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Background Diabetes is one of the leading causes of death and disability worldwide, and
affects people regardless of country, age group, or sex. Using the most recent evidentiary …

The WHO just released in May 2022 a report on the state of the obesity pandemic in Europe,
stating that 60% of citizens in the area of Europe are either overweight or obese, and …

Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

Background We assessed the efficacy and safety of the oral glucagon-like peptide-1
analogue, semaglutide 50 mg, taken once per day versus placebo for the treatment of …

Background Breast cancer is the most commonly diagnosed cancer and leading cause of
cancer death among women worldwide but has patterns and trends which vary in different …

Emerging evidence has spurred a considerable evolution of concepts relating to
atherosclerosis, and has called into question many previous notions. Here I review this …

One quarter of the global population is estimated to have nonalcoholic fatty liver disease
(NAFLD). The incidence of nonalcoholic steatohepatitis (NASH) is projected to increase by …

Obesity-related metabolic organ inflammation contributes to cardiometabolic disorders. In
obese individuals, changes in lipid fluxes and storage elicit immune responses in the …