The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Heart failure (HF) with preserved ejection fraction (HFpEF) is currently a preeminent
challenge for cardiovascular medicine. It has a poor prognosis, increasing mortality, and is …

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-
stimulated K ATP channel closure and insulin secretion. To identify the PK isoforms …

Background: Cellular redox control is maintained by generation of reactive oxygen/nitrogen
species balanced by activation of antioxidative pathways. Disruption of redox balance leads …

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most common
indication for heart transplantation. Currently, there is still an unmet clinical need in effective …

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiovascular disease with
heterogeneous clinical presentations, governed by multiple molecular mechanisms …

Dysregulated glycolysis has been noted in several pathological processes characterized by
supporting cell proliferation. Nonetheless, the role of glycolysis reprogramming is not well …

Myocardial fibrosis is the villain of sudden cardiac death. Myocardial ischemia/reperfusion
(MI/R) injury induces cardiomyocyte damage or even death, which in turn stimulates …

Background SENP1 (sentrin/small ubiquitin‐like modifier‐specific protease 1) has emerged
as a significant modulator involved in the pathogenesis of a variety of human diseases …

Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-
communicable disease deaths. Glycolysis is a conserved and rigorous biological process …