Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single
blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful …

Cardiometabolic disease is a major threat to global health. Precision medicine has great
potential to help to reduce the burden of this common and complex disease cluster, and to …

Cardiometabolic diseases are the leading preventable causes of death in most
geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic …

The purpose of precision dosing is to increase the chances of therapeutic success in
individual patients. This is achieved in practice by adjusting doses to reach precision dosing …

Background The handling of missing data is a challenge for inference and regression
modelling. A particular challenge is dealing with missing predictor information, particularly …

Objective Precision medicine requires reliable identification of variation in patient-level
outcomes with different available treatments, often termed treatment effect heterogeneity. We …

Introduction The management of chronic diabetes mellitus and its complications demands
customized glycaemia control strategies. Polypharmacy is prevalent among people with …

Abstract Combining a Sodium-Glucose-Cotransporter-2-inhibitor (SGLT2i) with metformin is
recommended for managing hyperglycemia in patients with type 2 diabetes (T2D) who have …

Background: A precision medicine approach in type 2 diabetes requires identification of
clinical and biological features that are reproducibly associated with differences in clinical …

The increasing prevalence of diabetes, obesity, and their cardiometabolic sequelae present
major global health challenges and highlight shortfalls of current approaches to the …