Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Eukaryotic cells activate the S-phase checkpoint in response to a variety of events affecting
the progression of replication forks, collectively referred to as replication stress. This …

Studies performed in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces
pombe have led the way in defining the DNA damage checkpoint and in identifying most of …

DNA double-strand breaks (DSBs) are among the most deleterious type of DNA lesions
threatening genome integrity. Homologous recombination (HR) and non-homologous end …

DNA replication is a highly demanding process regarding the energy and material supply
and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or …

The SLX4 Fanconi anemia protein is a tumor suppressor that may act as a key regulator that
engages the cell into specific genome maintenance pathways. Here, we show that the SLX4 …

Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation,
checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …

Summary The Mec1/Tel1 kinases (human ATR/ATM) play numerous roles in the DNA
replication stress response. Despite the multi-functionality of these kinases, studies of their …

A key function of the cellular DNA damage response is to facilitate the bypass of replication
fork-stalling DNA lesions. Template switch reactions allow such a bypass and involve the …