Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Glutamate carboxypeptidase II (GCPII) is a membrane-bound binuclear zinc
metallopeptidase with the highest expression levels found in the nervous and prostatic …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Modulation of N-acetyl-l-aspartyl-l-glutamate peptidase activity with small-molecule
inhibitors holds promise for a wide variety of diseases that involve glutamatergic …

Memantine received marketing authorization from the European Agency for the Evaluation
of Medicinal Products (EMEA) for the treatment of moderately severe to severe Alzheimer's …

A systematic characterization of compulsivity in pathological forms of eating has been
proposed in the context of three functional domains:(1) habitual overeating;(2) overeating to …

During the past 10 years, substantial progress has been made in the discovery and
development of small molecule glutamate carboxypeptidase II (GCP II) inhibitors. These …

It has been reported that N-methyl-d-aspartate (NMDA) receptor is implicated in drug
addiction and antagonists of the NMDA receptor complex can inhibit the development and …

Nearly two decades ago, Joe Coyle published a single-authored review with the provocative
title, The Nagging Question of the Function of N-Acetylaspartylglutamate (Coyle, 1997). In …