Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

Background Childhood trauma is a common and potent risk factor for developing major
depressive disorder in adulthood, associated with earlier onset, more chronic or recurrent …

Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …

Background Antidepressant medication and running therapy are both effective treatments for
patients with depressive and anxiety disorders. However, they may work through different …

Healthy aging is the process of preserving and enhancing one's independence, physical
and mental well-being, and overall quality of life. It involves the mental, emotional, and …

Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …

Over the past decades, the human life span has dramatically increased, and therefore, a
steady increase in diseases associated with age (such as Alzheimer's disease and …

Abstract Introduction The Dutch Brain Research Registry aims to facilitate online recruitment
of participants for brain disease studies. Methods Registrants were primarily recruited …

Impaired mitochondrial function and abnormalities in the tryptophan (Trp)-kynurenine (Kyn)
pathway are linked to age-related mood disorders. This study investigated the effect of …

Depression and anxiety are common and often comorbid mental health disorders that
represent risk factors for aging-related conditions. Brain aging has shown to be more …