Immune targets for therapeutic development in depression: towards precision medicine
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …
Treatment efficacy and effectiveness in adults with major depressive disorder and childhood trauma history: a systematic review and meta-analysis
E Kuzminskaite, AW Gathier, P Cuijpers… - The Lancet …, 2022 - thelancet.com
Background Childhood trauma is a common and potent risk factor for developing major
depressive disorder in adulthood, associated with earlier onset, more chronic or recurrent …
depressive disorder in adulthood, associated with earlier onset, more chronic or recurrent …
Charting brain growth and aging at high spatial precision
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …
deviations is essential for understanding inter-individual variability and its relation to the …
[HTML][HTML] Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders
JE Verhoeven, LKM Han, BA Lever-van Milligen… - Journal of affective …, 2023 - Elsevier
Background Antidepressant medication and running therapy are both effective treatments for
patients with depressive and anxiety disorders. However, they may work through different …
patients with depressive and anxiety disorders. However, they may work through different …
Healthy brain aging and delayed dementia in Texas rural elderly
T Basu, U Sehar, K Malhotra, J Culberson… - Ageing Research …, 2023 - Elsevier
Healthy aging is the process of preserving and enhancing one's independence, physical
and mental well-being, and overall quality of life. It involves the mental, emotional, and …
and mental well-being, and overall quality of life. It involves the mental, emotional, and …
Transdiagnostic evaluation of epigenetic age acceleration and burden of psychiatric disorders
N Yusupov, L Dieckmann, M Erhart, S Sauer… - …, 2023 - nature.com
Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …
been associated with multiple age-related diseases and mortality. Age acceleration in …
Inflamm-aging and brain insulin resistance: New insights and role of life-style strategies on cognitive and social determinants in aging and neurodegeneration
Y Komleva, A Chernykh, O Lopatina, Y Gorina… - Frontiers in …, 2021 - frontiersin.org
Over the past decades, the human life span has dramatically increased, and therefore, a
steady increase in diseases associated with age (such as Alzheimer's disease and …
steady increase in diseases associated with age (such as Alzheimer's disease and …
Dutch Brain Research Registry for study participant recruitment: design and first results
MD Zwan, WM van der Flier, S Cleutjens… - … Research & Clinical …, 2021 - Wiley Online Library
Abstract Introduction The Dutch Brain Research Registry aims to facilitate online recruitment
of participants for brain disease studies. Methods Registrants were primarily recruited …
of participants for brain disease studies. Methods Registrants were primarily recruited …
Mitochondrial transplantation improves anxiety-and depression-like behaviors in aged stress-exposed rats
G Javani, S Babri, F Farajdokht… - Mechanisms of Ageing …, 2022 - Elsevier
Impaired mitochondrial function and abnormalities in the tryptophan (Trp)-kynurenine (Kyn)
pathway are linked to age-related mood disorders. This study investigated the effect of …
pathway are linked to age-related mood disorders. This study investigated the effect of …
Contributing factors to advanced brain aging in depression and anxiety disorders
LKM Han, HG Schnack, RM Brouwer… - Translational …, 2021 - nature.com
Depression and anxiety are common and often comorbid mental health disorders that
represent risk factors for aging-related conditions. Brain aging has shown to be more …
represent risk factors for aging-related conditions. Brain aging has shown to be more …