FGF21 agonists: an emerging therapeutic for metabolic dysfunction-associated steatohepatitis and beyond

SA Harrison, T Rolph, M Knott, J Dubourg - Journal of Hepatology, 2024 - Elsevier
The worldwide epidemics of obesity, hypertriglyceridemia, dyslipidaemia, type 2 diabetes,
and metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction …

Erythropoietin mitigated thioacetamide-induced renal injury via JAK2/STAT5 and AMPK pathway

MA Elbaset, BMSA Mohamed, SA Gad, SM Afifi… - Scientific Reports, 2023 - nature.com
The kidney flushes out toxic substances and metabolic waste products, and homeostasis is
maintained owing to the kidney efforts. Unfortunately, kidney disease is one of the illnesses …

SIRT1/Nrf2/NF-κB signaling mediates anti-inflammatory and anti-apoptotic activities of oleanolic acid in a mouse model of acute hepatorenal damage

MAI Alqrad, DS El-Agamy, SRM Ibrahim, A Sirwi… - Medicina, 2023 - mdpi.com
Background and objectives: Oleanolic acid (OA) is a penta-cyclic triterpene with diverse
bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti …

Preparation and characterization of blank and nerolidol-loaded chitosan–alginate nanoparticles

RM Ahmad, YE Greish, HF El-Maghraby, L Lubbad… - Nanomaterials, 2022 - mdpi.com
Recently, there has been a growing interest in using natural products as treatment
alternatives in several diseases. Nerolidol is a natural product which has been shown to …

The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat

FT Hammad, S Al-Salam, R Ahmad, J Yasin… - Nutrients, 2023 - mdpi.com
Efforts to decrease the deleterious effects of renal ischemia–reperfusion injury (IRI) are
ongoing. Recently, there has been increasing interest in using natural phytochemical …

Renoprotective Effect of Pitavastatin against TAA‐Induced Renal Injury: Involvement of the miR‐93/PTEN/AKT/mTOR Pathway

MA Elbaset, BMSA Mohamed… - Advances in …, 2024 - Wiley Online Library
This research investigated if pitavastatin (Pita) might protect rats' kidneys against
thioacetamide (TAA). By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost …

[HTML][HTML] Unveiling the Potential of Silymarin, Spirulina platensis, and Chlorella vulgaris towards Cardiotoxicity via Modulating Antioxidant Activity, Inflammation, and …

HF El-Gendy, HK Khalifa, A Omran, RMS Korany… - Life, 2024 - mdpi.com
This study assessed the possible pharmacological effects of Chlorella vulgaris (Cg),
Spirulina platensis (St), and silymarin (Sl) against thioacetamide (TA)-induced cardiotoxicity …

[HTML][HTML] The ameliorating role of sofosbuvir and daclatasvir on thioacetamide-induced kidney injury in adult albino rats

AH Moustafa, HF Pasha, MA Abas… - Anatomy & Cell …, 2023 - synapse.koreamed.org
Thioacetamide (TAA) exposure and hepatitis C virus infection are usually associated with
renal dysfunction. Sofosbuvir (SFV) and daclatasvir (DAC) drugs combination has great …

[HTML][HTML] Curcumin alleviates thioacetamide-induced kidney toxicity in rats: enhancing antioxidant system, and attenuating oxidative stress, DNA damage, and …

AM Radwan, M Karhib, SA Fatoh… - Biomedical and …, 2023 - biomedpharmajournal.org
Abstract Thioacetamide (TAA), well-known as a toxic agent and has been reported to be
nephrotoxic due to oxidative stress induction and proinflammatory markers increase …

Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at …

S Zargar, TA Wani, S Alamery, F Yaseen - Medicina, 2024 - mdpi.com
Background and Objectives: TAA is potent hepatic/renal toxicant. Conversely, WGO is a
potent dietary supplement with impressive antioxidant properties. Olmutinib is an apoptotic …