Deciphering the impact of TERT/telomerase on immunosenescence and T cell revitalization

L Huang, M Zhang, D Bai, Y Qu - Frontiers in Immunology, 2024 - frontiersin.org
Immunosenescence impacts both the innate and adaptive immune systems, predominantly
affecting certain immune cell types. A notable manifestation of immunosenescence is the …

Mitochondria dysfunction and inflammation in traumatic brain injury: androgens to the battlefront

AJ McGovern, GE Barreto - Androgens: Clinical Research and …, 2021 - liebertpub.com
The therapeutic response to traumatic brain injury (TBI) still lacks a strategy to treat its acute
and chronic phases. Given that TBI affects the lives of 1.5 million people a year, and the …

[HTML][HTML] Network pharmacology identifies IL6 as an important hub and target of tibolone for drug repurposing in traumatic brain injury

AJ McGovern, GE Barreto - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Traumatic brain injury (TBI) is characterized by a complex network of signals mediating
inflammatory, proliferative and apoptotic processes during its acute and chronic phases …

Lipotoxicity, neuroinflammation, glial cells and oestrogenic compounds

O Hidalgo‐Lanussa, E Baez‐Jurado… - Journal of …, 2020 - Wiley Online Library
The high concentrations of free fatty acids as a consequence of obesity and being
overweight have become risk factors for the development of different diseases, including …

[HTML][HTML] Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury

GE Barreto, J Gonzalez, D Ramírez - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Traumatic brain injury (TBI) is a pathology of great social impact, affecting millions of people
worldwide. Despite the scientific advances to improve the management of TBI in recent …

Tibolone pre-treatment ameliorates the dysregulation of protein translation and transport generated by palmitic acid-induced lipotoxicity in human astrocytes: a label …

DJ Vesga-Jiménez, CA Martín-Jiménez… - International Journal of …, 2022 - mdpi.com
Excessive accumulation and release of fatty acids (FAs) in adipose and non-adipose tissue
are characteristic of obesity and are associated with the leading causes of death worldwide …

TERT silencing alters the expression of ARG1, GLUL, VIM, NES genes and hsa-miR-29b-3p in the T98G cell line

Y González-Giraldo, ÁYG Fonseca… - … Nucleotides & Nucleic …, 2023 - Taylor & Francis
The central function of telomerase is maintaining the telomere length. However, several
extra-telomeric roles have been identified for this protein complex. In this study, we …

Possible bradykinesia occurrence in lymphocyte division in Parkinson's disease

Yİ Gemici, İ Taşcı, M Dündar, N Özgen… - … of Experimental and …, 2024 - dergipark.org.tr
Lymphocytes have dopamine receptors, and low dopamine levels increase receptor
synthesis. Lymphocytes may move slower in Parkinson's, which is characterized by low …

Protective effect of conditioned medium from brain pericytes overexpressing telomerase reverse transcriptase on hypoxic-ischemic neurons

S Liu, L Huang, Z Zheng, M Zhang, H Li, F Zhao… - 2023 - researchsquare.com
Aims: Cerebral microvascular pericytes can secrete both neurotrophic factors and neurotoxic
molecules, which together construct the microenvironment for nerve growth and repair. The …

Possible bradykinesia occurrence in lymphocyte division in Parkinson's disease.

Y INALKAC GEMICI, I TASCI… - … of Experimental & …, 2024 - search.ebscohost.com
Lymphocytes have dopamine receptors, and low dopamine levels increase receptor
synthesis. Lymphocytes may move slower in Parkinson's, which is characterized by low …