We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational
treatment for various acquired and congenital disorders of mitochondrial intermediary …

Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading
cause of cancer death among men in Western countries. Current screening techniques are …

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical platform
employed to address a diversity of issues of research such as in understanding chemical …

Triphenyl phosphate (TPP) has been found in various environmental media and in biota
suggesting widespread human exposure. However, there is still insufficient information on …

Dichloroacetate (DCA) can reverse the glycolytic phenotype that is responsible of increased
lactate production and extracellular pH acidification in cancer cells. Magnetic resonance …

Unraveling molecular mechanisms that regulate tumor development and proliferation is of
the utmost importance in the quest to decrease the high mortality rate of adrenocortical …

Background Pyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by
pyruvate decarboxylation, which drives energy metabolism during cell growth, including …

Polycystic ovary syndrome (PCOS) is one of the most commonly occurring metabolic and
endocrinological disorders affecting women of reproductive age. Metabolomics is an …

The adverse effects of lactic acidosis in the cancer microenvironment have been
increasingly recognized. Dichloroacetate (DCA) is an orally bioavailable, blood brain barrier …

Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most
common urological cancers, and their incidence has been rising over time. Surgery is the …