Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway

S Ghafouri-Fard, Z Bahroudi, H Shoorei… - Cancer Cell …, 2022 - Springer
Abstract Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is a natural phenol that is present in
the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is …

Anti-fibrotic effects of nintedanib in lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

KE Hostettler, J Zhong, E Papakonstantinou… - Respiratory …, 2014 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor
prognosis. The kinase inhibitor nintedanib specific for vascular endothelial growth factor …

Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation

T Ishii - Free Radical Biology and Medicine, 2015 - Elsevier
Inflammation is a complex biological self-defense reaction triggered by tissue damage or
infection by pathogens. Acute inflammation is regulated by the time-and cell type-dependent …

In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar

AR Phull, M Majid, I Haq, MR Khan, SJ Kim - International journal of …, 2017 - Elsevier
Seaweed and their constituents have been traditionally employed for the management of
various human pathologic conditions such as edema, urinary disorders and inflammatory …

Mechanism research on a bioactive resveratrol–PLA–gelatin porous nano-scaffold in promoting the repair of cartilage defect

F Yu, M Li, Z Yuan, F Rao, X Fang, B Jiang… - International journal …, 2018 - Taylor & Francis
Background Articular cartilage defects are difficult to treat, but drug-loaded tissue
engineering scaffolds provide a possible treatment option for these types of injuries …

Taurocholate induces cyclooxygenase-2 expression via the sphingosine 1-phosphate receptor 2 in a human cholangiocarcinoma cell line

R Liu, X Li, X Qiang, L Luo, PB Hylemon, Z Jiang… - Journal of Biological …, 2015 - ASBMB
Cholangiocarcinoma (CCA) is a rare, but highly malignant primary hepatobiliary cancer with
a very poor prognosis and limited treatment options. Our recent studies reported that …

Metals-triggered compound CDPDP exhibits anti-arthritic behavior by downregulating the inflammatory cytokines, and modulating the oxidative storm in mice models …

SS Hassan, SQ Abbas, I Muhammad, JJ Wu… - Frontiers in …, 2022 - frontiersin.org
Triggering through abiotic stress, including chemical triggers like heavy metals, is a new
technique for drug discovery. In this research, the effect of heavy metal Nickel on …

[HTML][HTML] The thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and …

SM Yu, SJ Kim - International journal of molecular …, 2015 - spandidos-publications.com
Dedifferentiation and inflammation are major features of cartilage degeneration during the
pathogenesis of osteoarthritis (OA). Thymoquinone (TQ) is the major compound of black …

[HTML][HTML] Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6 in human articular chondrocytes via TLR4/MyD88-dependent and-independent …

H Gu, Y Jiao, X Yu, X Li, W Wang… - … journal of molecular …, 2017 - spandidos-publications.com
The natural polyphenolic compound, resveratrol, has been shown to exhibit anti-
osteoarthritic activity. Therefore it is hypothesized that resveratrol may serve as a nutritional …

Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage

M Maepa, M Razwinani, S Motaung - Journal of ethnopharmacology, 2016 - Elsevier
Ethnopharmacological relevance Resveratrol (RSV) was first isolated in 1940 from the roots
of white hellebore (Veratrum grandiflorum (Maxim. ex Miq) O. Loes) and in 1963 from the …