[HTML][HTML] Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications

K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …

The many faces of estrogen signaling

P Vrtačnik, B Ostanek, S Mencej-Bedrač, J Marc - Biochemia medica, 2014 - hrcak.srce.hr
Sažetak Estrogens have long been known as important regulators of the female
reproductive functions; however, our understanding of the role estrogens play in the human …

MicroRNAs as potential biomarkers in cancer: opportunities and challenges

H Lan, H Lu, X Wang, H Jin - BioMed research international, 2015 - Wiley Online Library
MicroRNAs (miRNAs) are a group of small noncoding RNAs (ncRNAs) that
posttranscriptionally regulate gene expression by targeting their corresponding messenger …

[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology

R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

[HTML][HTML] The oncogenic role of Jagged1/Notch signaling in cancer

M Xiu, Y Liu, B Kuang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Aberrant activation of Notch signaling plays an oncogenic role in cancer development.
Jagged1 (JAG1) is an important Notch ligand that triggers Notch signaling through cell-cell …

miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2

J Wei, Y Shi, L Zheng, B Zhou, H Inose, J Wang… - Journal of cell …, 2012 - rupress.org
A screen of microRNAs preferentially expressed in osteoblasts identified members of the
miR-34 family as regulators of osteoblast proliferation and/or differentiation. Osteoblast …

[HTML][HTML] HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells

CM Klinge, KM Piell, CS Tooley, EC Rouchka - Scientific reports, 2019 - nature.com
MicroRNAs are dysregulated in breast cancer. Heterogeneous Nuclear Ribonucleoprotein
A2/B1 (HNRNPA2/B1) is a reader of the N (6)-methyladenosine (m6A) mark in primary …

[HTML][HTML] From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment

R Piva, DA Spandidos… - … journal of oncology, 2013 - spandidos-publications.com
MicroRNAs (miRNAs or miRs) are a family of small non‑coding RNAs that regulate gene
expression by the sequence-selective targeting of mRNAs, leading to translational …

MicroRNAs as biomarker for breast cancer

T Aggarwal, R Wadhwa, R Gupta… - … Metabolic & Immune …, 2020 - ingentaconnect.com
Regardless of advances in detection and treatment, breast cancer affects about 1.5 million
women all over the world. Since the last decade, genome-wide association studies (GWAS) …

[HTML][HTML] Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer

MX Liu, MKY Siu, SS Liu, JWP Yam, HYS Ngan… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Epithelial ovarian cancer is a highly lethal and aggressive gynecological malignancy. The
high mortality rate is due in part to the fact that many advanced cancer patients become …