The mammalian alimentary tract harbors hundreds of species of commensal
microorganisms (microbiota) that intimately interact with the host and provide it with genetic …

Complex mechanisms are pulling the strings to initiate the development of inflammatory
bowel disease. Current evidence indicates that an interaction of genetic susceptibilities …

Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-
derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment …

Stromal cells are a subject of rapidly growing immunological interest based on their ability to
influence virtually all aspects of innate and adaptive immunity. Present in every bodily tissue …

Dendritic cells (DCs) are specialized sentinels responsible for coordinating adaptive
immunity. This function is dependent upon coupled sensitivity to environmental signs of …

Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract
caused by a spectrum of genetic and environmental factors. In mice, overlapping regions of …

Inflammatory bowel disease (IBD) is an immune-mediated condition driven by improper
responses to intestinal microflora in the context of environmental and genetic background …

T-bet−/−. Rag2−/−(TRUC) mice spontaneously develop microbiota-driven, TNF-mediated
large bowel inflammation that resembles human ulcerative colitis. We show here that IL-23 …

In most natural environments, the large majority of mammals harbour parasitic helminths that
often live as adults within the intestine for prolonged periods (1–2 years). Although these …

Changes in the spatial organization, or biogeography, of colonic microbes have been
observed in human inflammatory bowel disease (IBD) and mouse models of IBD. We have …