Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
Following Alzheimer's, Parkinson's disease (PD) is the second-most common
neurodegenerative disorder, sharing an unclear pathophysiology, a multifactorial profile …

Management of motor and non-motor symptoms in Parkinson's disease

F Sprenger, W Poewe - CNS drugs, 2013 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder that
affects approximately 1% of people over the age of 60 years. Accurate diagnosis and …

EuroInf 2: subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease

HS Dafsari, P Martinez‐Martin, A Rizos… - Movement …, 2019 - Wiley Online Library
Objective Real‐life observational report of clinical efficacy of bilateral subthalamic
stimulation (STN‐DBS), apomorphine (APO), and intrajejunal levodopa infusion (IJLI) on …

Levodopa‐carbidopa intestinal gel in advanced Parkinson's disease: final 12‐month, open‐label results

HH Fernandez, DG Standaert, RA Hauser… - Movement …, 2015 - Wiley Online Library
Motor complications in Parkinson's disease (PD) are associated with long‐term oral
levodopa treatment and linked to pulsatile dopaminergic stimulation. l‐dopa‐carbidopa …

Initial experience of the levodopa–entacapone–carbidopa intestinal gel in clinical practice

M Öthman, E Widman, I Nygren, D Nyholm - Journal of Personalized …, 2021 - mdpi.com
Patients in fluctuating stages of Parkinson's disease (PD) require device-aided treatments.
Continuous infusion of levodopa–carbidopa intestinal gel (LCIG) is a well-proven option in …

Therapies for Parkinson's disease and the gut microbiome: evidence for bidirectional connection

G Hey, N Nair, E Klann, A Gurrala… - Frontiers in Aging …, 2023 - frontiersin.org
The gut brain axis (GBA), a bidirectional communication pathway has often been linked to
health and disease, and gut microbiota (GM), a key component of this pathway shown to be …

Levodopa–carbidopa intestinal gel in patients with Parkinson's disease: a systematic review

K Wirdefeldt, P Odin, D Nyholm - CNS drugs, 2016 - Springer
Background Levodopa–carbidopa intestinal gel (LCIG) is available in several countries for
the treatment of advanced levodopa-responsive Parkinson's disease (PD) with severe motor …

Integrated safety of levodopa‐carbidopa intestinal gel from prospective clinical trials

AE Lang, RL Rodriguez, JT Boyd… - Movement …, 2016 - Wiley Online Library
Background Continuous administration of levodopa‐carbidopa intestinal gel (carbidopa‐
levodopa enteral suspension) through a percutaneous endoscopic gastrojejunostomy is a …

Long‐term safety and efficacy of levodopa‐carbidopa intestinal gel in advanced Parkinson's disease

HH Fernandez, JT Boyd, VSC Fung, MF Lew… - Movement …, 2018 - Wiley Online Library
Background: Levodopa‐carbidopa intestinal gel (designated as carbidopa‐levodopa enteral
suspension in the United States) provides stable plasma levodopa concentrations and …

Algorithms for the treatment of motor problems in Parkinson's disease

E Dietrichs, P Odin - Acta Neurologica Scandinavica, 2017 - Wiley Online Library
Several different strategies are effective for medical treatment of motor problems in
Parkinson's disease (PD). Many guidelines and evidence‐based reviews are available, but …