Failure of normal brain development leads to mental retardation or autism in about 3% of
children. Many genes integral to pathways by which synaptic modification and the …

Williams syndrome, a rare disorder caused by hemizygous microdeletion of about 28 genes
on chromosome 7q11. 23, has long intrigued neuroscientists with its unique combination of …

We have undertaken a genome-wide analysis of rare copy-number variation (CNV) in 1124
autism spectrum disorder (ASD) families, each comprised of a single proband, unaffected …

Several microtubule binding proteins, including CLIP-170 (cytoplasmic linker protein-170),
CLIP-115, and EB1 (end-binding protein 1), have been shown to associate specifically with …

The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for
schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the …

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2
(LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several …

Williams syndrome has been variably termed Williams–Beuren syndrome, idiopathic
hypercalcemia, and supravalvar aortic stenosis syndrome. It is estimated to occur in …

Microtubule plus-end-tracking proteins (+ TIPs) are a diverse group of molecules that display
dynamic accumulation at the distal ends of growing microtubules. Specific binding to the …

A unique opportunity to understand genetic determinants of cognition is offered by Williams
syndrome (WS), a well-characterized hemideletion on chromosome 7q11. 23 that causes …

To address the natural history of Williams syndrome (WS), we performed multisystem
assessments on 20 adults with WS over 30 years of age and documented a high frequency …