The contributions of prostate cancer stem cells in prostate cancer initiation and metastasis
Research in the last decade has clearly revealed a critical role of prostate cancer stem cells
(PCSCs) in prostate cancer (PC). Prostate stem cells (PSCs) reside in both basal and …
(PCSCs) in prostate cancer (PC). Prostate stem cells (PSCs) reside in both basal and …
Polycomb group (PcG) proteins and human cancers: multifaceted functions and therapeutic implications
Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial
developmental and physiological processes in the cell. More recently, they have been found …
developmental and physiological processes in the cell. More recently, they have been found …
The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells
Y Nishida, A Maeda, MJ Kim, L Cao, Y Kubota… - Blood cancer …, 2017 - nature.com
Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML).
Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re …
Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re …
[HTML][HTML] The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: a Boolean model of cell death
S Gupta, DA Silveira, JCM Mombach… - Non-coding RNA …, 2023 - Elsevier
Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …
Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells
HO Caglar, C Biray Avci - Molecular biology reports, 2020 - Springer
The cell cycle is a complex and strictly controlled process, consisting of different phases.
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The …
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The …
Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation
Natural and synthetic progestogens have been commonly used to prevent recurrent
pregnancy loss in women with inadequate progesterone secretion or reduced progesterone …
pregnancy loss in women with inadequate progesterone secretion or reduced progesterone …
Integrated bioinformatics analysis of potential biomarkers for pancreatic cancer
H Shi, H Xu, C Chai, Z Qin… - Journal of Clinical …, 2022 - Wiley Online Library
Background Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is an
aggressive malignancy associated with a low 5‐year survival rate. Poor outcomes …
aggressive malignancy associated with a low 5‐year survival rate. Poor outcomes …
Cancer stem cell biomarkers in egfr-mutation–positive non–small-cell lung cancer
J Codony-Servat, C Codony-Servat, AF Cardona… - Clinical Lung Cancer, 2019 - Elsevier
Introduction Epidermal growth factor receptor (EGFR) pathway deregulation promotes the
acquisition of stemlike properties in non–small-cell lung cancer. EGFR inhibition through …
acquisition of stemlike properties in non–small-cell lung cancer. EGFR inhibition through …
[HTML][HTML] Assessment of biochemical recurrence of prostate cancer
X Lin, A Kapoor, Y Gu, MJ Chow… - International …, 2019 - spandidos-publications.com
The assessment of the risk of biochemical recurrence (BCR) is critical in the management of
males with prostate cancer (PC). Over the past decades, a comprehensive effort has been …
males with prostate cancer (PC). Over the past decades, a comprehensive effort has been …
miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin
N Patel, KR Garikapati, RK Pandita, DK Singh… - Scientific reports, 2017 - nature.com
The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as
an oncogene in various cancers, including breast cancer. Recent evidence suggests that …
an oncogene in various cancers, including breast cancer. Recent evidence suggests that …