The contributions of prostate cancer stem cells in prostate cancer initiation and metastasis

W Mei, X Lin, A Kapoor, Y Gu, K Zhao, D Tang - Cancers, 2019 - mdpi.com
Research in the last decade has clearly revealed a critical role of prostate cancer stem cells
(PCSCs) in prostate cancer (PC). Prostate stem cells (PSCs) reside in both basal and …

Polycomb group (PcG) proteins and human cancers: multifaceted functions and therapeutic implications

W Wang, JJ Qin, S Voruganti, S Nag… - Medicinal research …, 2015 - Wiley Online Library
Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial
developmental and physiological processes in the cell. More recently, they have been found …

The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells

Y Nishida, A Maeda, MJ Kim, L Cao, Y Kubota… - Blood cancer …, 2017 - nature.com
Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML).
Relapse is driven by leukemia stem cells, a chemoresistant subpopulation capable of re …

[HTML][HTML] The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: a Boolean model of cell death

S Gupta, DA Silveira, JCM Mombach… - Non-coding RNA …, 2023 - Elsevier
Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …

Alterations of cell cycle genes in cancer: unmasking the role of cancer stem cells

HO Caglar, C Biray Avci - Molecular biology reports, 2020 - Springer
The cell cycle is a complex and strictly controlled process, consisting of different phases.
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The …

Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation

Q Xin, S Kong, J Yan, J Qiu, B He… - The Journal of …, 2018 - Am Soc Clin Investig
Natural and synthetic progestogens have been commonly used to prevent recurrent
pregnancy loss in women with inadequate progesterone secretion or reduced progesterone …

Integrated bioinformatics analysis of potential biomarkers for pancreatic cancer

H Shi, H Xu, C Chai, Z Qin… - Journal of Clinical …, 2022 - Wiley Online Library
Background Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is an
aggressive malignancy associated with a low 5‐year survival rate. Poor outcomes …

Cancer stem cell biomarkers in egfr-mutation–positive non–small-cell lung cancer

J Codony-Servat, C Codony-Servat, AF Cardona… - Clinical Lung Cancer, 2019 - Elsevier
Introduction Epidermal growth factor receptor (EGFR) pathway deregulation promotes the
acquisition of stemlike properties in non–small-cell lung cancer. EGFR inhibition through …

[HTML][HTML] Assessment of biochemical recurrence of prostate cancer

X Lin, A Kapoor, Y Gu, MJ Chow… - International …, 2019 - spandidos-publications.com
The assessment of the risk of biochemical recurrence (BCR) is critical in the management of
males with prostate cancer (PC). Over the past decades, a comprehensive effort has been …

miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

N Patel, KR Garikapati, RK Pandita, DK Singh… - Scientific reports, 2017 - nature.com
The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as
an oncogene in various cancers, including breast cancer. Recent evidence suggests that …