Executive summary “Depression is a disorder of mood, so mysteriously painful and elusive
in the way it becomes known to the self—to the mediating intellect—as to verge close to …

Mental disorders represent a worldwide public health concern. Psychotherapies and
pharmacotherapies are recommended as first line treatments. However, evidence has …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Treatments for depression have improved, and their availability has markedly increased
since the 1980s. Mysteriously the general population prevalence of depression has not …

Systematic reviews seek to identify all research that meets the eligibility criteria. However,
this goal can be compromised by 'non‐reporting bias'. The convincing evidence for the …

Individuals with substance use disorders (SUDs) are at increased risk for COVID‐19
infection and for adverse outcomes of the infection. Though vaccines are highly effective …

Background This meta-analysis of randomized controlled trials (RCTs) examines the efficacy
of physical exercise as treatment for unipolar depression, both as an independent …

Importance Relapse prevention in recurrent depression is a significant public health
problem, and antidepressants are the current first-line treatment approach. Identifying an …

Objective: In the past decades, many different types of psychotherapy for adult depression
have been developed. Method: In this meta-analysis we examined the effects of 15 different …

We report the current best estimate of the effects of cognitive behavior therapy (CBT) in the
treatment of major depression (MDD), generalized anxiety disorder (GAD), panic disorder …