Mechanisms of ketamine and its metabolites as antidepressants
EM Hess, LM Riggs, M Michaelides… - Biochemical pharmacology, 2022 - Elsevier
Treating major depression is a medical need that remains unmet by monoaminergic
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
therapeutic strategies that commonly fail to achieve symptom remission. A breakthrough in …
NMDA receptor functions in health and disease: Old actor, new dimensions
N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …
A vicious cycle of β amyloid–dependent neuronal hyperactivation
β-amyloid (Aβ)–dependent neuronal hyperactivity is believed to contribute to the circuit
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although …
Impairment of glycolysis-derived l-serine production in astrocytes contributes to cognitive deficits in Alzheimer's disease
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …
Mechanisms of NMDA receptor regulation
L Mony, P Paoletti - Current opinion in neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …
expressed in the central nervous system that play key role in brain development and …
Regulation of NMDA glutamate receptor functions by the GluN2 subunits
The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+ influx …
Synaptic GluN2A-containing NMDA receptors: from physiology to pathological synaptic plasticity
L Franchini, N Carrano, M Di Luca… - International journal of …, 2020 - mdpi.com
N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors.
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or …
[HTML][HTML] GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
S Bossi, D Dhanasobhon, GCR Ellis-Davies, J Frontera… - Neuron, 2022 - cell.com
GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions
in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits …
in the brain are mostly unknown. Here, we show that the expression of GluN3A subunits …
Unconventional NMDA receptor signaling
In the classical view, NMDA receptors (NMDARs) are stably expressed at the postsynaptic
membrane, where they act via Ca 2+ to signal coincidence detection in Hebbian plasticity …
membrane, where they act via Ca 2+ to signal coincidence detection in Hebbian plasticity …
Sex differences in psychiatric disease: a focus on the glutamate system
MM Wickens, DA Bangasser, LA Briand - Frontiers in molecular …, 2018 - frontiersin.org
Alterations in glutamate, the primary excitatory neurotransmitter in the brain, are implicated
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …
in several psychiatric diseases. Many of these psychiatric diseases display epidemiological …