Cytomegalovirus latency and reactivation: an intricate interplay with the host immune response
CMV is an ancient herpesvirus that has co-evolved with its host over millions of years. The
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
236 kbp genome encodes at least 165 genes, four non-coding RNAs and 14 miRNAs. Of the …
[HTML][HTML] The emerging role of human cytomegalovirus infection in human carcinogenesis: a review of current evidence and potential therapeutic implications
CS Nauclér, J Geisler, K Vetvik - Oncotarget, 2019 - ncbi.nlm.nih.gov
It is well-established that infections with viruses harboring oncogenic potential increase the
cancer risk. Virus induced oncogenic processes are influenced by a complex and unique …
cancer risk. Virus induced oncogenic processes are influenced by a complex and unique …
[HTML][HTML] ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission
Human cytomegalovirus (HCMV) is the most common vertically transmitted infection
worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) …
worldwide, yet there are no vaccines or therapeutics to prevent congenital HCMV (cCMV) …
HCMV latency: what regulates the regulators?
E Elder, J Sinclair - Medical microbiology and immunology, 2019 - Springer
Human cytomegalovirus (HCMV) latency and reactivation is regulated by the chromatin
structure at the major immediate early promoter (MIEP) within myeloid cells. Both cellular …
structure at the major immediate early promoter (MIEP) within myeloid cells. Both cellular …
Viral G Protein–Coupled Receptors Encoded by β-and γ-Herpesviruses
MM Rosenkilde, N Tsutsumi, JM Knerr… - Annual review of …, 2022 - annualreviews.org
Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …
HCMV antivirals and strategies to target the latent reservoir
Human cytomegalovirus (HCMV) is a ubiquitous human herpesvirus. In healthy people,
primary infection is generally asymptomatic, and the virus can go on to establish lifelong …
primary infection is generally asymptomatic, and the virus can go on to establish lifelong …
The complex biology of human cytomegalovirus latency
F Goodrum - Advances in virus research, 2022 - Elsevier
While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …
response or by death of the host, other viruses establish long-term relationships with the …
How can we improve vaccination response in old people? Part I: targeting immunosenescence of innate immunity cells
A Aiello, ME Ligotti, M Garnica, G Accardi… - International Journal of …, 2022 - mdpi.com
Vaccination, being able to prevent millions of cases of infectious diseases around the world
every year, is the most effective medical intervention ever introduced. However …
every year, is the most effective medical intervention ever introduced. However …
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus
VM Vlahava, I Murrell, L Zhuang… - The Journal of …, 2021 - Am Soc Clin Investig
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease
following congenital infection and in immunocompromised individuals. No vaccines are …
following congenital infection and in immunocompromised individuals. No vaccines are …
Modulation of host cell signaling during cytomegalovirus latency and reactivation
NA Smith, GC Chan, CM O'Connor - Virology Journal, 2021 - Springer
Background Human cytomegalovirus (HCMV) resides latently in cells of the myeloid
compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes …
compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes …