Transcription factors (TFs) constitute a wide and highly diverse group of proteins capable of
controlling gene expression. Their roles in oncogenesis, tumor progression, and metastasis …

Ovarian cancer (OC) is the fifth leading cause of women's death from cancers. The high
mortality rate is attributed to the late presence of the disease and the lack of modern …

The identification of VHL-binding proteolysis targeting chimeras (PROTACs) that potently
degrade the BRM protein (also known as SMARCA2) in SW1573 cell-based experiments is …

A hallmark feature of lens development and differentiation is the complete elimination of
organelles from the center of the eye lens. A long unanswered question in lens biology is …

Mammalian SWI/SNF (mSWI/SNF) complexes are ATP-dependent chromatin remodeling
enzymes that are critical for normal cellular functions. mSWI/SNF enzymes are classified into …

The SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex is one of
the most remarkably altered epigenetic regulators in cancer. Pathogenic mutations in genes …

The investigation into viral latency illuminates its pivotal role in the survival strategies of
diverse viruses, including herpesviruses, HIV, and HPV. This underscores the delicate …

Cohesin is a highly conserved, multiprotein complex whose canonical function is to hold
sister chromatids together to ensure accurate chromosome segregation. Cohesin …

Plant immune responses involve transcriptional reprograming of defense response genes,
and chromatin remodeling is important for transcriptional regulation. However, nucleosome …

Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly
related to cancer initiation. Thus, sensitive and specific detection of epigenetic modifications …