Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

Bovine milk-derived exosomes have recently emerged as a promising nano-vehicle for the
encapsulation and delivery of macromolecular biotherapeutics. Here we engineer high …

Pulmonary delivery of nanomedicines is very promising in lung local disease treatments
whereas several physiological barriers limit its application via the interaction with inhaled …

Lipid nanoparticles are increasingly used for drug and gene delivery, including the delivery
of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid …

The efficacy of drugs administered by traditional routes is limited by numerous biological
barriers that preclude reaching the intended site of action. Further, full body systemic …

Cystic fibrosis (CF) is a genetic disease affecting today nearly 70,000 patients worldwide
and characterized by a hypersecretion of thick mucus difficult to clear arising from the …

Mucus is a densely populated ecological niche that coats all non-keratinized epithelia, and
plays a critical role in protecting the human body from infections. Although traditionally …

Mucus is a complex hydrogel that acts as a protective barrier in various parts of the human
body. Both composition and structural properties play a crucial role in maintaining barrier …

The Oral route of administration forms the heartwood of the ever-growing tree of drug
delivery technology. It is one of the most preferred dosage forms among patients and …