Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …

Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …

Mutations in the human VPS13 genes are responsible for neurodevelopmental and
neurodegenerative disorders including chorea acanthocytosis (VPS13A) and Parkinson's …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the
mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 …

Mitochondria form close physical associations with the endoplasmic reticulum (ER) that
regulate a number of physiological functions. One mechanism by which regions of ER are …

Abstract α-Synuclein is strongly linked to Parkinson's disease but the molecular targets for its
toxicity are not fully clear. However, many neuronal functions damaged in Parkinson's …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

The contact sites that the endoplasmic reticulum (ER) forms with mitochondria, called
mitochondria-associated membranes (MAMs), are a hot topic in biological research, and …