Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell
disease. Symptomatic management and prevention of these events using the fetal …

Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical
features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin …

BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in
patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic …

With the global scope of sickle-cell disease, knowledge of the countless clinical
presentations and treatment of this disorder need to be familiar to generalists …

Mammalian gene silencing is established through methylation of histones and DNA,
although the order in which these modifications occur remains contentious. Using the …

Based on a prospective cohort study of 1056 patients with sickle cell anemia (Hb SS)
initiated in 1959, we investigated the influence of calendar era, age, sex, and prior medical …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …