The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Neuroimaging has been widely adopted in psychiatric research, with hopes that these non-
invasive methods will provide important clues to the underpinnings and prediction of various …

Recent research has highlighted the role of complement genes in shaping the
microstructure of the brain during early development, and in contributing to common allele …

Background Increased expression of the complement component 4A (C4A) gene is
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …

Abstract Introduction The apolipoprotein E (APOE) ɛ2 allele reduces risk against
Alzheimer's disease (AD) but mechanisms underlying this effect are largely unknown …

Postsynaptic density is reduced in schizophrenia, and risk variants increasing complement
component 4A (C4A) gene expression are linked to excessive synapse elimination. In two …

BackgroundInflammation plays a crucial role in the pathogenesis of major depressive
disorder (MDD) and bipolar disorder (BD). This study aimed to examine whether the …

Abstract Background Excessive C4A-gene expression may result in increased microglia-
mediated synaptic pruning. As C4A overexpression is observed in schizophrenia spectrum …

Complex brain disorders like schizophrenia may have multifactorial origins related to mis-
timed heritable and environmental factors interacting during neurodevelopment. Infections …

Up-regulation of the complement component 4A (C4A) in the brain has been associated with
excessive synaptic pruning and increased schizophrenia (SZ) susceptibility. Over …