Conspectus The cyclic GMP-AMP synthase-stimulator interferon gene (cGAS-STING)
pathway is an emerging therapeutic target for the prophylaxis and therapy of a variety of …

Nucleic acid sensing is involved in viral infections, immune response-related diseases, and
therapeutics. Based on the composition of nucleic acids, nucleic acid sensors are defined as …

Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

We have previously described polyglutamine-binding protein 1 (PQBP1) as an adapter
required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response to the human …

Background The poor prognosis of subarachnoid hemorrhage (SAH) is often attributed to
neuroinflammation. The cGAS-STING axis, a cytoplasmic pathway responsible for detecting …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

The activation of cyclic GMP–AMP synthase (cGAS) by double-stranded DNA is implicated
in the pathogenesis of many hyperinflammatory and autoimmune diseases, and the cGAS …

Abstract Background Interleukin-33 (IL-33), defined as" alarming", exert diverse functions
through signaling via the suppression of tumorigenicity 2 (ST2). However, the physiological …

Fungal keratitis is a serious corneal infection, which can lead to significant visual impairment
and blindness. The cGAS-STING signaling pathway has emerged as a key player in innate …

Genomic instability is a key driving force for the development and progression of many
neurodegenerative diseases and central nervous system (CNS) cancers. The initiation of …